Nutrigenomics and athletic performance. Case study of an adolescent player of the National soccer team

Authors

  • Κonstantinos Ntakoulas DNA GOLDFORCE
  • Νikolaos Mantzouranis Democritus University of Thrace
  • Ioannis Ispyrlidis Democritus University of Thrace

Keywords:

health, gene, polymorphism, training

Abstract

 The aim of this case study was to evaluate the nutritional genomes profile of a soccer player by analyzing the interaction between genes and nutritional habits related to metabolism. The genetic analysis was conducted on a soccer player from the National U17 team, aged 16 years, with stature of 175cm and body mass 66kg. The GOLDFORCE DNA ATHLETIC TEST utilizing an epithelial sample analyzed the effects of 11 genes on the player’s health, nutrition, and physical performance. The results showed that out of the genes analyzed in terms of the player’s nutrigenomics, four exhibited positive genotypes, three displayed neutral genotypes and three genes demonstrated negative genotypes. The evaluation of genes associated with metabolism (ADRB2, ADRB1, MCHR1, CETP) revealed that the athlete does not possess an inherited risk of obesity, exhibits efficient lipid metabolism, and has a high rate of thermogenesis. The analysis of the CYP1A2_1C gene demonstrated a satisfactory stimulatory response to caffeine, while the HFE gene confirmed the athlete’s ability to absorb iron effectively. In conclusion, the insights provided by predispositional nutrigenomics could help mitigate genetic limitations and capitalize on the athlete’s genetic advantages, thereby facilitating a safe advancement towards a successful career in soccer.

References

Akhabue, Ε., Thiboutot, J., Cheng, J.W., Vittorio, J.T., Christodoulidis, G., Grady, M.K., Lerakis, S., & Kosmas, E.C. (2014). New and emerging risk factors for coronary heart disease American Journal of the Medical Science, 347(2):151-158. doi: 10.1097/MAJ.0b013e31828aab45.

Beck, K.L., Thomson, J.S., Swift, R.J., & von Hurst, P.R. (2015). Role of nutrition in performance enhancement and postexercise recovery. Open Access Journal of Sports Medicine, 259–267.

Bray, M.S., Hagberg, J.M., Pérusse, L., Rankinen, T., Roth, S.M., Wolfarth, B., & Bouchard, C. (2009). The human gene map for performance and health-related fitness phenotypes: The 2006–2007 update. Medicine and Science in Sports and Exercise, 41(1), 35–73.

Brites, D.F., Evelson, A.P., Christiansen, M.G., Nicol, F.M., Basilico, H.M., Wikinski, W.R., & Llesuy, F.S. (1999). Soccer players under regular training show oxidative stress but an improved plasma antioxidant status. Clinical Science, 96(4), 381-385.

Brutsaert, T.D., & Parra, E.J. (2006). What makes a champion? Explaining variation in human athletic performance. Respiratory Physiology & Neurobiology, 151(2-3), 109-123, doi: 10.1016/j.resp.2005.12.013.

Burke, L.M., & Hawley, A.J. (2018). Swifter, higher, stronger: What's on the menu? Science, 362 (6416), 781-787. doi: 10.1126/science.aau2093.

Calo, C.M., & Vona, G. (2008). Gene polymorphisms and elite performance. Journal of Anthropological Sciences, 86, 113-131.

Carlberg, C. (2023). Genomic signaling of vitamin D. Steroids, 198, 109271. doi: 10.1016/j.steroids.2023

Chong, M.F., Fielding, B.A., & Frayn, K.N. (2007). Metabolic interaction of dietary sugars and plasma lipids with a focus on mechanisms and de novo lipogenesis. Proceedings of the Nutrition Society, 66(1), 52-59.

Coelho, B.D., Pimenta, M.E., Rosse, C.I., Veneroso, C., De Azambuja Pussieldi, G., Becker, K.L., Oliveira, C.E. Carvalho, R.S.M., & Silami-Garcia, E. (2019). Alpha-Actinin-3 R577X Polymorphism Influences Muscle Damage and Hormonal Responses after a Soccer Game. Journal of Strength and Conditioning Research, 33(10), 2655-2664. doi: 10.1519/JSC.0000000000002575.

Del Coso, J., & Lucia, A. (2021). Genetic Influence in Exercise Performance. Genes, 12(651), 1-5. Diogenes, M.E., Bezerra, F.F., Cabello, G.M., Cabello, P.H., Mendonça, L.M., Oliveira Júnior, A.V., & Donangelo C.M. (2010). Vitamin D receptor gene FokI polymorphisms influence bone mass in adolescent football (soccer) players. European Journal of Applied Physiology, 108(1), 31-38.

Duyuler, S. (2019). Myocardial Performance in Elite Athletes: The Role of Homocysteine, Iron, and Lipids. Medicine Science Monitor, 14(25), 1194-1203. doi: 10.12659/MSM.913561.

Δανιάς, Π., Ντάκουλας, Κ., Μαντζουράνης, Ν., & Χασκή, Δ. (2023). Γονιδιακός έλεγχος για την πρόβλεψη της αγωνιστικής απόδοσης στην καλαθοσφαίριση. Μελέτη περίπτωσης παίκτη της BASKET LEAGUE. Φυσική Αγωγή & Αθλητισμός, 43(1), 102-104.

Epstein, D. (2010). Sports Genes. Sports Illustrated, May 17, 53-65.

Guest, N.S., Corey, P., Tyrrell, P.N., & El-Sohemy, A. (2022). Effect of Caffeine on Endurance Performance in Athletes May Depend on HTR2A and CYP1A2 Genotypes. Journal of Strength and Conditioning Research, 36(9), 2486–2492.

Iaia, F.M., Rampinini, E., & Bangsbo, J. (2009). High-intensity training in football. International Journal of Sports Physiology and Performance, 4(3), 291-306.

Iskandar F.C., Cailliez-Grimal, C., Rahman, A., Rondags, E., Remenant, B., Zagorec, M., Leisner, J.J., Borges, F., Revol-Junelles, A-M (2016). Genes associated to lactose metabolism illustrate the high diversity of Carnobacterium maltaromaticum. Food Microbiology, 58, 79-86.

Knechtle, B., Jastrzebski Z., Hill L., & Nikolaidis T.P. (2021). Vitamin D and Stress Fractures in Sport: Preventive and Therapeutic Measures-A Narrative Review. Medicina, 57(3), 223, https://doi.org/10.3390/medicina57030223.

Κουκλιαμπής, Μ., Ντάκουλας, Κ., Μαντζουράνης, Ν. Αλεξίου, Β., & Γεμενετζής, Ν. (2023). Γονιδιακός έλεγχος για την πρόβλεψη της ευαισθησίας σε τραυματισμούς. Μελέτη περίπτωσης σε ποδοσφαιριστή αναπτυξιακής ηλικίας. Φυσική Αγωγή & Αθλητισμός, 43(1), 104-106.

Lapo, H.M., Chacon-Mikahil, M.P.T., & Sardeli, A.V. (2022). Pre-competitive overload period impairs parasympathetic modulation in athletes: A systematic review and meta-analysis. Physiology & Behaviour, 250(1), 113780. https://doi.org/10.1016/j.physbeh.2022.113780.

Lucia, A., Moran, M., Zihong, H., & Ruiz, J.R. (2010). Elite Athletes: Are the genes the champions? International Journal of Sports Physiology and Performance, 5(1), 98-102.

MacArthur, D.G., & North, K.N. (2007). ACTN3: A genetic influence on muscle function and athletic performance. Exercise and Sport Sciences Reviews, 35(1), 30-34.

Massidda, M., Eynon, N., Bachis, V., Corrias, L., Culigioni, C., Cugia, P., Scorcu, M., & Calo, C.M. (2016). Association Between MCT1 A1470T Polymorphism and Fat-Free Mass in Well-Trained Young Soccer Players. Journal of Strength and Conditioning Research, 30(4), 1171-1176. doi: 10.1519/JSC.0000000000001176.

McCabe, K., & Collins, C. (2018). Can genetics predict injury? The association of the genes GDF5, AMPD1, COL5A1 and IGF2 on Soccer player injury occurrence. Sports, 6(1), 1-10.

Pizzorno, J. (2014). Homocysteine: Friend or foe? Integrative Medicine, 13(4), 8-14.

Pludowski, P., Holick, M.F., Grant, W.B., Konstantynowicz, J., Mascarenhasn, M.R., Haq, A., Povoroznyuk, V., Balatska, N., Barbosa, A.P., Karonova, T., Rudenka, E., Misiorowski, W., Zakharova, I., Rudenka, A., Łukaszkiewicz, J., Marcinowska-Suchowierska, E., Łaszcz, N., Abramowicz, P., Bhattoa, H.P., & Wimalawansa, S.J. (2018). Vitamin D supplementation guidelines. Journal of Steroid Biochemical and Molecular Biology, 175, 125–135.

Puthucheary, Z., Skipworth, J.R.A., Rawal, J., Loosemore, M., Someren, K.W., & Montgomery, H.E. (2011). Genetic influences in sport and physical performance. Sports Medicine, 41(10), 845-859.

Reilly, T., Lees, A., Davids, K., & Murphy, W.J. (1988). Science and Football, (95-107). London: E & FN Spon: Chapman & Hall.

Resin, A., Gatteschi, L., Giamberardino, M.A., Imreh, F., Rubenni, M.G., & Vecchiet, L. (1991). Haematological comparison of iron status in trained top-level soccer players and monitoring subjects. International Journal of Sports Medicine, 12, (Suppl. 5), 453-456.

Santiago, P. (2012). Ferrous versus ferric oral iron formulations for the treatment of iron deficiency: a clinical overview. Scientific World Journal. 846824. doi: 10.1100/2012/846824.

Semenova, A.E., Hall, E.C.R., & Ahmetov, I.I. (2023). Genes and Athletic Performance: The 2023 Update, Genes, 14(1235), 1-32. https://doi.org/10.3390/genes14061235

Sharma, D., Singh, A., Verma, K., Paliwal, S., Sharma, S., & Dwivedi, J. (2017). Fluoride: A review of pre-clinical and clinical studies. Environmental Toxicology & Pharmacology, 56, 297-313. doi: 10.1016/j.etap.2017.10.008.

Stastny, P., Lehnert, M., De Ste Croix, M., Petr, M., Svoboda, Z., Maixnerova, E., Varekova, R., Botek, M., Petrek, M., Kocourkova, L., & Cieszczyk, P. (2019). Effect of COL5A1, GDF5, and PPARA Genes on a Movement Screen and Neuromuscular Performance in Adolescent Team Sport Athletes. Journal of Strength and Conditioning Research, 33(8), 2057-2065. doi:10.1519/JSC.0000000000003142.

Stoffel, N.U., von Siebenthal, H.K., Moretti, D., & Zimmermann, M.B. (2020). Oral iron supplementation in iron-deficient women: How much and how often? Molecular Aspects of Medicine. doi: 10.1016/j.mam.2020.100865.

Stølen, T., Chamari, K., Castagna, C., & Wisløff, U. (2005). Physiology of soccer. Sports Medicine, 35(6), 501-536.

Thevis, M., Thomas, A., & Schänzer, W. (2010). Insulin. Handbook of Experimental Pharmacology, 195, 209-226.

Womack, C.J., Saunders, M.J., Bechtel, M.K., Bolton, D.J., Martin, M., Luden, N.D., Dunham, W., & Hancock, M. (2012). The influence of a CYP1A2 polymorphism on the ergogenic effects of caffeine. Journal of International Society in Sport Nutrition, 9, 7.

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Published

2025-06-17

How to Cite

Ntakoulas Κ., Mantzouranis Ν., & Ispyrlidis, I. (2025). Nutrigenomics and athletic performance. Case study of an adolescent player of the National soccer team. Exercise and Society, 1, 434–447. Retrieved from https://ojs.itlabs.duth.gr/index.php/ExSoc/article/view/567

Issue

Vol. 1 (2025): Special Issue 76

Section

PART III: SCIENTIFIC SELECTIONS BY THE FACULTY MEMBERS OF THE D.P.E.S.S.–D.U.ThH

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